产品货号：
Z18505
中文名称：
ING4抗体
英文名称：
Anti-ING4 Antibody
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ING4 Antibody |
| 指标别名 | ING4;Inhibitor of growth protein 4;my036;p29ING4 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | ELISA,WB |
| 基因名称 | ING4 |
| 抗体来源 | Goat |
| 抗体类型 | IgG |
| 免疫原 | This affinity purified antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region near aa 150-175 of Human p29 ING4 protein (Inhibitor of growth family,member 4).This sequence only shows homology to isoform 1 for ING4. |
| 计算分子量 | 29kDa |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | This is an affinity purified antibody produced by immunoaffinity chromatography using the immunizing peptide after immobilization to a solid phase.Reactivity occurs against human p29 ING4 protein.The sequence is not present in isoforms 2 (see below).However,100% homology is on record for this protein from human,dog,rat,and mouse.Cross-reactivity with p29 ING4 protein from chimpanzee and chicken sources is also expected based on high homology (one amino acid change in sequence) by BLAST.Reactivity with p29 ING4 proteins from other sources is not known. |
| 浓度 | 1.28mg/mL by UV absorbance at 280nm |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | p29 ING4 is a tumor suppressor protein similar to ING1 that may inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation.p29 ING4 has been shown to suppress brain tumor angio-genesis through transcriptional repression of RelA/NFKB3 target genes when complexed with RelA.p29 ING4 may also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC.p29 ING4 shows a nuclear localization and interacts with EP300,TP53,RelA,inhibits cell growth,and induces apoptosis.This protein contains a PHD-finger,which is a common motif in proteins involved in chromatin remodeling.Multiple alternatively spliced transcript variants have been observed.The accession number listed below is for variant (1) that encodes the longest isoform. |
| Uniprot ID | Q9UNL4 |
| 基因名全称 | Inhibitor of growth protein 4 |
| 推荐稀释比 | ELISA:1:3,000 - 1:12,000 WB:1:500 - 1:3,000 |
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